THE DUAL ROLE OF CXCL9/SPP1 POLARIZED TUMOR-ASSOCIATED MACROPHAGES IN MODULATING ANTI-TUMOR IMMUNITY IN HEPATOCELLULAR CARCINOMA

The dual role of CXCL9/SPP1 polarized tumor-associated macrophages in modulating anti-tumor immunity in hepatocellular carcinoma

IntroductionThe main challenge for cancer therapy lies in immuno-suppressive tumor micro-environment.Reprogramming tumor-associated macrophages (TAMs) into an anti-tumor phenotype is a promising strategy.MethodsA comprehensive analysis by combing multi-regional single-cell, bulk and spatial transcriptome profiling with radiomics characterization wa

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Fire Activity and Fuel Consumption Dynamics in Sub-Saharan Africa

African landscape fires are widespread, recurrent and temporally dynamic.They Magnets burn large areas of the continent, modifying land surface properties and significantly affect the atmosphere.Satellite Earth Observation (EO) data play a pivotal role in capturing the spatial and temporal variability of African biomass burning, and provide the key

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Canadian Society of Nephrology Commentary on the Kidney Disease Improving Global Outcomes 2017 Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder

Purpose of review: (1) To provide commentary on the 2017 update to the Kidney Disease Improving Global Outcomes (KDIGO) 2017 Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD); (2) to apply the evidence-based guideline update for implementation wi

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Safety and Efficacy of Oral Melatonin When Combined with Thoracic Epidural Analgesia in Patients with Bilateral Multiple Fracture Ribs

Ahmed M Fetouh Abdelrahman,1 Amany Faheem Abdel Salam Omara,1 Alaa Ali M Elzohry2 1Anesthesia and Surgical ICU, Faculty of Medicine, Tanta University, Tanta, Egypt; 2Department of Anesthesia, ICU and Pain Relief, South Egypt Cancer Institute, Assiut University, Assiut, EgyptCorrespondence: Alaa Ali M ElzohryDepartment of Anesthesia, ICU and Pain Re

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